Benzodiazepine withdrawal: an unfinished story.

Benzodiazepine withdrawal: an unfinished story.

"'I am 39 years old, married, with two children aged 18 years and 14 years. The younger was a very active baby, and when he was 18 months old I mentioned to the doctor that he was sleeping very little and though he did not seem tired in any way, I certainly was! After a course of vitamins I still felt worn out and this was when I was first prescribed Valium. "This was 1971; I was then 27 years ...

The Human Transcriptome: An Unfinished Story

Despite recent technological advances, the study of the human transcriptome is still in its early stages. Here we provide an overview of the complex human transcriptomic landscape, present the bioinformatics challenges posed by the vast quantities of transcriptomic data, and discuss some of the studies that have tried to determine how much of the human genome is transcribed. Recent evidence has...

[Diabetes mellitus, thiazolidinediones and fractures: an unfinished story].

The association of diabetes mellitus with increased fracture risk is well established, and is observed in both diabetes type 1 and type 2, due to multiple causes. Evidence from rodents suggests that thiazolidinediones (TZD), by activation of PPAR-gamma, cause increased bone marrow adiposity, with decreased osteoblastogenesis resulting in bone loss. Initial studies in humans evidence higher frac...

The unfinished story of family medicine transformation.

The benzodiazepine withdrawal syndrome and its management.

The literature on benzodiazepine dependence and withdrawal is reviewed with an emphasis on social and psychological considerations. The problems of when to prescribe, identifying withdrawal symptoms, effective communication with the patient, the structure of withdrawal programmes, and the use of drugs, psychological approaches and other services are discussed.